CDX2 Antibody (AMT28) Summary
| Immunogen |
Prokaryotic recombinant protein corresponding to the 180 amino acid N-terminal region of the human CDX2 molecule.
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| Localization |
Nuclear
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CDX2
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| Purity |
Tissue culture supernatant
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Immunohistochemistry (paraffin-embedded sections): ABC method with a suggested incubation period of 60 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1 mM EDTA buffer, pH 8.0 prior to immunostaining.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
No buffer
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| Preservative |
0.05% Sodium Azide
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| Purity |
Tissue culture supernatant
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Alternate Names for CDX2 Antibody (AMT28)
- caudal type homeo box transcription factor 2
- caudal type homeobox 2
- Caudal-type homeobox protein 2
- CDX2
- CDX3
- CDX-3
- CDX3caudal type homeobox transcription factor 2
- homeobox protein CDX-2
Background
CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.