CDK5 Activator 1 Antibody (4G11) Summary
| Immunogen |
CDK5R1 (AAH20580, 208 a.a. – 307 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. CRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
|
| Specificity |
CDK5R1 – cyclin-dependent kinase 5, regulatory subunit 1 (p35)
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CDK5R1
|
| Purity |
IgG purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against transfected lysate and recombinant protein for WB. It has been used for ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for CDK5 Activator 1 Antibody (4G11)
- CDK5 Activator 1
- CDK5P35
- CDK5R
- CDK5R1
- cyclin-dependent kinase 5 activator 1
- Cyclin-dependent kinase 5 regulatory subunit 1
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- MGC33831
- NCK5A
- Neuronal CDK5 Activator
- p23
- p25
- p35
- p35nck5a
- regulatory partner for CDK5 kinase
- tau protein kinase II 23kDa subunit
- TPKII Regulatory Subunit
Background
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimers disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimers disease.