CD99 Antibody (MEM-131) Summary
| Immunogen |
HPB-ALL human peripheral blood leukemia T-cell line
|
| Specificity |
The antibody MEM-131 reacts with CD99R, an epitope restricted to a subset of CD99 molecule expressed on myeloid cells, NK cells and T lymphocytes. HLDA V; WS Code AS S020 HLDA V; WS Code T T-E2.02 HLDA V; WS Code T T-017
|
| Isotype |
IgM
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD99
|
| Purity |
Ammonium sulfate precipitation
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western Blot: Use under non-reducing conditions. Antibody purity is > 95% (by SDS-PAGE).
|
Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS (approx. pH 8.0)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Ammonium sulfate precipitation
|
Alternate Names for CD99 Antibody (MEM-131)
- 12E7
- antigen identified by monoclonal antibodies 12E7, F21 and O13
- CD99 antigenY homolog
- CD99 molecule
- CD99
- E2 antigen
- HBA71
- MIC2 (monoclonal 12E7)
- MIC2
- MIC2Y
- MSK5X
- pilr-1
- PILR-L
- Protein MIC2
- surface antigen MIC2
- T-cell surface glycoprotein E2
Background
CD99 (E2, MIC2) is a transmembrane glycoprotein that is involved in regulation of T cell addhesive properties and programmed cell death distinct from typical apoptosis course. CD99 roles are specific to certain stages of T cell differentiation such as corticothymocytes. CD99R isoform expression is restricted in the haematopoietic system to T, NK and myeloid cells.