Product: Pentamidine (isethionate)
CD8 beta Antibody (341) Summary
| Immunogen |
The immunogen for this antibody was CD8b.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD8B
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
This antibody is reactive to Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous, may contain carrier protein/stabilizer.
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CD8 beta Antibody (341)
- CD8 antigen, beta polypeptide 1 (p37)
- CD8 beta
- CD8b antigen
- CD8b molecule
- CD8b
- CD8B1
- CD8B1P37
- Leu2
- LY3
- LYT3
- MGC119115
- P37
- T lymphocyte surface glycoprotein beta chain
- T-cell surface glycoprotein CD8 beta chain
Background
The 341 monoclonal antibody reacts with rat CD8beta. CD8beta is a member of the immunoglobulin superfamily which heterodimerizes with CD8alpha to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages. CD8beta expression is absent in athymic mice, which are populated by T-cells expressing CD8alpha homodimers. This has led to the idea that CD8beta expression is dependent on the development of T cells in the thymus. CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck.