Product: EVP-6124 (hydrochloride)
CD79A Antibody (HM57) Summary
| Immunogen |
A synthetic peptide corresponding to aa 202-216 (GTYQDVGSLNIADVQ) of human CD79a protein.
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| Localization |
Cell surface
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| Specificity |
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CD79A
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IHC: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
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| Theoretical MW |
44 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Human, Monkey, Pig, Cow, Mouse and Rat
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
10mM PBS with 0.05% BSA
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| Preservative |
0.05% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for CD79A Antibody (HM57)
- CD79A antigen (immunoglobulin-associated alpha)
- CD79a antigen
- CD79a molecule, immunoglobulin-associated alpha
- CD79A
- IGAB-cell antigen receptor complex-associated protein alpha chain
- ig-alpha
- MB-1 membrane glycoprotein
- MB1
- MB-1
- Membrane-bound immunoglobulin-associated protein
- Surface IgM-associated protein