CD74 Antibody (CerCLIP.1) Summary
| Immunogen |
Synthetic peptide derived from the sequence of human CLIP
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD74
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Publications |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.9% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for CD74 Antibody (CerCLIP.1)
- CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated)
- CD74 antigen
- CD74 molecule, major histocompatibility complex, class II invariant chain
- CD74
- CLIP
- DHLAG
- DHLAGgamma chain of class II antigens
- HLA class II histocompatibility antigen gamma chain
- HLADG
- HLA-DR antigens-associated invariant chain
- HLA-DR-gamma
- Ia antigen-associated invariant chain
- Ia-associated invariant chain
- Ia-gamma
- Ii
- INVG34
- MHC HLA-DR gamma chain
- p33
Background
CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells.