CD74 Antibody (CLIP/1133) Summary
| Immunogen |
Recombinant full-length human CD74 protein
|
| Localization |
Cell surface and paranuclear globular
|
| Marker |
B-Cell Marker
|
| Specificity |
Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD74
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Hu-chromosome location: 5q33.1
Molecular weight of antigen: 33-41kDa |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CD74 Antibody (CLIP/1133)
- CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated)
- CD74 antigen
- CD74 molecule, major histocompatibility complex, class II invariant chain
- CD74
- CLIP
- DHLAG
- DHLAGgamma chain of class II antigens
- HLA class II histocompatibility antigen gamma chain
- HLADG
- HLA-DR antigens-associated invariant chain
- HLA-DR-gamma
- Ia antigen-associated invariant chain
- Ia-associated invariant chain
- Ia-gamma
- Ii
- INVG34
- MHC HLA-DR gamma chain
- p33