CD4 Antibody (GK1.5) Summary
| Immunogen |
Mouse CTL clone V4
|
| Specificity |
CD4/L3T4a, Mr 52 kDa
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
CD4
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Flow Cytometry, Immunohistochemistry, Immunoprecipitation, In vivo and in vitro depletion of CD4+ cells, Inhibition of T helper function, Fractionation of CD4+ cells
|
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
0.1M BBS (pH 8.2)
|
| Preservative |
No Preservative
|
| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CD4 Antibody (GK1.5)
- CD4 antigen (p55)
- CD4 antigen
- CD4 molecule
- CD4 receptor
- CD4
- CD4mut
- T-cell surface antigen T4/Leu-3
- T-cell surface glycoprotein CD4
Background
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes (“helper/inducer” T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.