CD46 Antibody (MEM-258) [Biotin] Summary
| Immunogen |
HPB-ALL human T cell line
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| Specificity |
The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
|
| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
|
| Gene |
CD46
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
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| Readout System |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
15mM Sodium Azide
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| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
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Alternate Names for CD46 Antibody (MEM-258) [Biotin]
- AHUS2
- CD46 antigen
- CD46 molecule, complement regulatory protein
- CD46
- MCP
- membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
- MIC10
- TLXcomplement regulatory protein
- trophoblast leucocyte common antigen
- Trophoblast leukocyte common antigen
- trophoblast-lymphocyte cross-reactive antigen
Background
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.