CD45 Antibody (2B11) [FITC] Summary
| Immunogen |
Isolated neoplastic cells from T cell lymphoma
|
| Specificity |
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PTPRC
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Optimal dilution of this antibody should be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for CD45 Antibody (2B11) [FITC]
- B220
- CD45 antigen
- CD45
- CD45R
- EC 3.1.3.48
- LCA
- L-CA
- LY5
- protein tyrosine phosphatase, receptor type, C
- PTPRC
- receptor-type tyrosine-protein phosphatase C
- T200 Glycoprotein
- T200 leukocyte common antigen
- T200receptor type, c polypeptide