CD25/IL-2 R alpha Antibody (280401) – Azide Free Summary
| Immunogen |
Partial recombinant mouse CD25/IL2Ra protein (amino acids 22-236) [UniProt P01590].
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
IL2RA
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
No Preservative
|
| Concentration |
0.51 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CD25/IL-2 R alpha Antibody (280401) – Azide Free
- CD25 antigen
- CD25
- IDDM10
- IL-2 R alpha
- IL-2 receptor subunit alpha
- IL2R alpha
- IL-2R subunit alpha
- IL2R
- IL2RA
- IL-2Ra
- IL-2-RA
- IL2-RA
- interleukin 2 receptor, alpha
- interleukin-2 receptor subunit alpha
- p55
- TAC antigen
- TCGFR
Background
CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.