CD23/Fc epsilon RII Antibody (EBVCS2) [PE/Cy7] Summary
| Immunogen |
The immunogen for this antibody was CD23.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
FCER2
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The EBVCS2 antibody has been tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
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| Preservative |
0.09% Sodium Azide
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| Purity |
Protein A or G purified
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Alternate Names for CD23/Fc epsilon RII Antibody (EBVCS2) [PE/Cy7]
- BLAST-2
- CD23
- CD23A
- CD23CD23 antigen
- CLEC4J
- CLEC4JC-type lectin domain family 4 member J
- C-type lectin domain family 4, member J
- Fc epsilon RII
- Fc fragment of IgE, low affinity II, receptor for (CD23)
- FCE2Fc fragment of IgE, low affinity II, receptor for (CD23A)
- fc-epsilon-RII
- FCER2
- Fcer2a
- FceRII
- IGEBF
- Immunoglobulin E-binding factor
- low affinity immunoglobulin epsilon Fc receptor
- Ly-42
- Lymphocyte IgE receptor
Background
The EBVCS2 monoclonal antibody reacts with human CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on mature B cells, mantle zone B cells, follicular dendritic cells and at low levels on T, NK, langerhans cells and platelets. Expression of CD23 is upregulated upon B cell activation, and soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B cell activation. CD21 and the alpha subunit of CD11b and CD11c bind to CD23.