CD23/Fc epsilon RII Antibody (Bu38) Summary
| Immunogen |
Made to Human CD23
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| Specificity |
NB100-64362 recognizes the human low affinity IgE Fc receptor, CD23, a 45kD that exists in two isoforms CD23a and CD23b, which differ in their cytoplasmic regions. The CD23a molecule is primarily expressed on B-cells. Whereas the CD23a molecule is expressed on activated B-cells and weakly on other haematopoietic cells including a subset of peripheral blood T-cells, natural killer cells, granulocytes and follicular dendritic cells. A soluble 25-30kD form of CD23 also exists. Membrane CD23 is reported to play a role in the down-regulation of IgE production.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
FCER2
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| Purity |
Protein G purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Protein G purified
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Alternate Names for CD23/Fc epsilon RII Antibody (Bu38)
- BLAST-2
- CD23
- CD23A
- CD23CD23 antigen
- CLEC4J
- CLEC4JC-type lectin domain family 4 member J
- C-type lectin domain family 4, member J
- Fc epsilon RII
- Fc fragment of IgE, low affinity II, receptor for (CD23)
- FCE2Fc fragment of IgE, low affinity II, receptor for (CD23A)
- fc-epsilon-RII
- FCER2
- Fcer2a
- FceRII
- IGEBF
- Immunoglobulin E-binding factor
- low affinity immunoglobulin epsilon Fc receptor
- Ly-42
- Lymphocyte IgE receptor
Background
The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a