CCR6 Antibody

Product: GTS-21 (dihydrochloride)

CCR6 Antibody Summary

Immunogen
Synthetic peptide: YFVSVNTSYYSVDSEMLLCSLQEVRQFSR, corresponding to amino acids 18-46 of Human CCR6.
Localization
Integral membrane protein
Clonality
Polyclonal
Host
Goat
Gene
CCR6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:250
  • ELISA 1:37500
  • Flow Cytometry 2-6 ul/10^6 cells in 100ul
  • Immunohistochemistry 1:125
  • Immunohistochemistry-Paraffin 1:125
Positive Control
CCR6 Lysate (NBL1-08893)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR6 Antibody

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.

PMID: 22821963

CCR6 Antibody

Product: INCB 3285

CCR6 Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from 2nd extracellular domain of human CCR6.
Specificity
Human CCR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Clonality
Polyclonal
Host
Rabbit
Gene
CCR6
Purity
Immunogen affinity purified
Innovators Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2 ug/ml-9 ug/ml
Positive Control
CCR6 Lysate (NBL1-08893)
Reviewed Applications
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using
NLS356 in the following application:

  • Immunohistochemistry-Paraffin

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (89%), Opossum (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR6 Antibody

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a Chemokine Receptor that is activated by MIP3alpha/Larc binding. CCR6 has been shown to be upregulated in psoriatic skin. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells but not in natural killer cells, monocytes, or granulocytes from spleen, lymph node, appendix, and fetal liver. ESTs have been isolated from liver/spleen, lymph, and fetal lung/testis/B cell libraries.

PMID: 12070310