CCR10/GPR2 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from 2nd extracellular domain of human CCR10.
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| Specificity |
Human CCR10. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Rabbit (94%), Bovine (94%), Monkey (94%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CCR10
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (94%), Panda (94%), Gibbon (88%), Mouse (88%), Rat (88%), Hamster (88%), Elephant (88%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CCR10/GPR2 Antibody
- CC chemokine receptor 10
- C-C chemokine receptor type 10
- C-C CKR-10
- CC-CKR-10
- CCR10
- CCR-10
- chemokine (C-C motif) receptor 10
- G protein-coupled receptor 2
- GPR2
- GPR2G-protein coupled receptor 2
Background
GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation. GRP2/CCR10 has been reported to be ubiquitously expressed. Transcripts for this receptor have been identified in peripheral tissues including adult small intestine and fetal liver, testis, placenta, and skin. In the skin, this receptor is constitutively expressed in melanocytes, fibroblasts, and microvascular endothelial cells. It is also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in keratinocytes (Homey et al., 2000), dendritic cells, or in various brain regions (Marchese et al., 1994). ESTs have been isolated from brain, eye, and kidney libraries.