CCL11/Eotaxin Antibody Summary
| Immunogen |
Antibody was raised in rabbits against a peptide corresponding to amino acids near the carboxy terminus of human eotaxin. The immunogen is located within the last 50 amino acids of Eotaxin.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CCL11
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| Purity |
Ion exchange chromatography
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Eotaxin antibody can be used for detection of eotaxin by Western blot at 0.5 to 1 mg/ml. The recombinant protein can be used as positive control and monomer and homodimer are detected at approximate 9 and 18 kDa.
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| Theoretical MW |
11 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Ion exchange chromatography
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Alternate Names for CCL11/Eotaxin Antibody
- C-C motif chemokine 11
- CCL11
- chemokine (C-C motif) ligand 11
- Eosinophil chemotactic protein
- Eotaxin
- eotaxin-1
- MGC22554
- SCYA11Small-inducible cytokine A11
- small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
Background
Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia and eotaxin inhibits the infection of HIV-1.