Bub3 Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human bub3. The immunogen is located within the last 50 amino acids of Bub3.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
BUB3
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Bub3 Antibody
- BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog
- BUB3 budding uninhibited by benzimidazoles 3 homolog
- Bub3
- BUB3L
- budding uninhibited by benomyl
- budding uninhibited by benzimidazoles 3 homolog (yeast)
- hBUB3
- mitotic checkpoint component
- mitotic checkpoint protein BUB3
Background
The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.