Bcl-2 Antibody (BCL2/796) [DyLight 680]

Product: Trimebutine

Bcl-2 Antibody (BCL2/796) [DyLight 680] Summary

Immunogen
Recombinant full-length human bcl-2 protein
Localization
Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes.
Marker
Apoptosis & Follicular Lymphoma Marker
Specificity
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
BCL2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody shomld be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Bcl-2 Antibody (BCL2/796) [DyLight 680]

  • apoptosis regulator Bcl-2
  • B-cell CLL/lymphoma 2
  • Bcl2
  • Bcl-2

PMID: 11040338