Bcl-10 Antibody (151)

Product: 3,6-Dicaffeoylquinic acid

Bcl-10 Antibody (151) Summary

Immunogen
Recombinant full length protein (Human).
Epitope
The epitope recognized by the antibody resides within amino acids 122-168 of human Bcl 10 molecule.
Localization
Cytoplasmic. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.
Specificity
Bcl 10 (151)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BCL10
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
IHC-P: Perform heat mediated antigen retrieval before commencing with IHC staining protocol. WB: Detects bands of approximately 20, 32 and 37 kDa.
Positive Control
Raji Lysate (NB820-59466)
Publications
Read Publications using
NB600-1403 in the following applications:

  • ELISA
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
10mM PBS (pH 7.4)
Preservative
15mM Sodium Azide
Concentration
2.0 mg/ml
Purity
Protein A purified

Alternate Names for Bcl-10 Antibody (151)

  • B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
  • Bcl10
  • Bcl-10
  • CARD-containing apoptotic signaling protein
  • CARD-containing molecule enhancing NF-kappa-B
  • CARD-containing proapoptotic protein
  • CARD-like apoptotic protein
  • CARMEN
  • caspase-recruiting domain-containing protein
  • cCARMEN
  • c-E10
  • c-E10bcl-10
  • CED-3/ICH-1 prodomain homologous E10-like regulator
  • Cellular homolog of vCARMEN
  • cellular-E10
  • CIPER
  • CLAP
  • hCLAP
  • Mammalian CARD-containing adapter molecule E10
  • mE10
  • mE10CARD containing molecule enhancing NF-kB

Background

Bcl 10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl 10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl 10 cellular overexpression induces JNK, p38, and NF-kappaB activation. Deregulation of Bcl 10 expression was also demonstrated to be involved in cellular oncogenesis.

PMID: 25936372