Bcl-10 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human BCL10. The exact sequence is proprietary.
|
| Localization |
Cytoplasm; perinuclear region
|
| Predicted Species |
Rat (96%), Porcine (96%), Monkey (99%), Bovine (99%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BCL10
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Rhesus Monkey (99%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Bcl-10 Antibody
- B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
- Bcl10
- Bcl-10
- CARD-containing apoptotic signaling protein
- CARD-containing molecule enhancing NF-kappa-B
- CARD-containing proapoptotic protein
- CARD-like apoptotic protein
- CARMEN
- caspase-recruiting domain-containing protein
- cCARMEN
- c-E10
- c-E10bcl-10
- CED-3/ICH-1 prodomain homologous E10-like regulator
- Cellular homolog of vCARMEN
- cellular-E10
- CIPER
- CLAP
- hCLAP
- Mammalian CARD-containing adapter molecule E10
- mE10
- mE10CARD containing molecule enhancing NF-kB
Background
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]