BNIP3L Antibody Summary
| Immunogen |
peptide (DAQHESGQSSSRGSSH)corresponding to amino acids 77 to 92 of human origin,which are identical to those of mouse Bnip3L (3).
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| Specificity |
Bnip 3L
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
BNIP3L
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in western blot, where monomeric band of approximately 40 kDa is detected.
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| Positive Control |
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| Publications |
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Reactivity Notes
Human and Mouse. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
0.05% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for BNIP3L Antibody
- Adenovirus E1B19K-binding protein B5
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
- BCL2/adenovirus E1B 19kDa interacting protein 3-like
- BNIP3a
- BNIP3H
- BNIP3L
- Nip3L
- NIP3-like protein X
- Nix
- NIXBCL2/adenovirus E1B 19kD-interacting protein 3-like
Background
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growingsubclass of the Bcl-2 family. A novel BH3 domaincontaining protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.).Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Over expression of Bnip3L induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L interacts withand overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3Lis localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.