BIRC8 Antibody Summary
| Immunogen |
Synthetic peptide from human BIRC8 / ILP2.
|
| Specificity |
synthetic peptide corresponding to amino acids near the amino terminus of human ILP-2
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BIRC8
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for BIRC8 Antibody
- baculoviral IAP repeat containing 8
- baculoviral IAP repeat-containing 8
- baculoviral IAP repeat-containing protein 8
- hILP2
- IAP-like protein 2
- ILP-2ILP2
- Inhibitor of apoptosis-like protein 2
- Testis-specific inhibitor of apoptosis
Background
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.