BCAM/CD239 Antibody (BRIC221) Summary
| Immunogen |
Human erythrocytes
|
| Specificity |
NB100-66523 recognizes a non-polymorphic determinant on both the 85 and 78kD Lutheran (Lu) glycoproteins. BRIC 221 specifically recognizes an epitope in the fourth extracellular domain of Lu glycoprotein. Lutheran glycoprotein is a member of the immunoglobulin superfamily and has recently been designated CD239 (B-CAM) at the 7th leucocyte typing workshop. CD239 is expressed by erythrocytes in the peripheral blood.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
BCAM
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
Non-reducing conditions required in Western Blotting.
|
||
| Positive Control |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Tris-Glycine
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for BCAM/CD239 Antibody (BRIC221)
- antigen identified by monoclonal F8
- Auberger B antigen
- basal cell adhesion molecule (Lu and Au blood groups)
- basal cell adhesion molecule (Lutheran blood group)
- basal cell adhesion molecule
- B-CAM cell surface glycoprotein
- BCAM
- B-cell adhesion molecule
- CD239 antigen
- CD239
- F8/G253 antigen
- glycoprotein 95kDa
- LUAU
- Lutheran antigen
- Lutheran blood group (Auberger b antigen included)
- Lutheran blood group glycoprotein
- MSK19
Background
CD239 glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. CD239 is expressed by erythrocytes in the peripheral blood and may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.