BACE-2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human BACE2. The exact sequence is proprietary.
|
| Localization |
Membrane
|
| Predicted Species |
Bovine (90%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BACE2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
56 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (88%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.83 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for BACE-2 Antibody
- AEPLC
- Asp 1
- ASP1
- ASP21
- Aspartic-like protease 56 kDa
- Aspartyl protease 1
- BACE2
- BACE-2
- beta secretase 2
- beta-secretase 2
- beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
- Beta-site amyloid precursor protein cleaving enzyme 2
- Beta-site APP cleaving enzyme 2
- beta-site APP-cleaving enzyme 2
- beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease
- CEAP1
- Down region aspartic protease
- Down syndrome region aspartic protease
- DRAPBAE2
- EC 3.4.23
- EC 3.4.23.45
- memapsin-1
- Membrane-associated aspartic protease 1
- theta-secretase
- transmembrane aspartic proteinase Asp1
Background
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the Down critical region of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]