BACE-1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human BACE1. The exact sequence is proprietary.
|
| Localization |
Membrane
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BACE1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
56 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus tropicalis (84%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for BACE-1 Antibody
- APP beta-secretase
- ASP2
- Aspartyl protease 2
- BACE1
- BACE-1
- BACEAsp 2
- beta-secretase 1 precursor variant 1
- beta-secretase 1
- beta-site amyloid beta A4 precursor protein-cleaving enzyme
- Beta-site amyloid precursor protein cleaving enzyme 1
- Beta-site APP cleaving enzyme 1
- beta-site APP-cleaving enzyme 1
- beta-site APP-cleaving enzyme
- EC 3.4.23
- EC 3.4.23.46
- FLJ90568
- HSPC104
- KIAA1149
- memapsin-2
- Membrane-associated aspartic protease 2
- transmembrane aspartic proteinase Asp2
Background
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]