B7-1/CD80 Antibody (MEM-233) Summary
| Immunogen |
Extracellular domain of human CD80 fused to human IgG1(Fc)
|
| Localization |
Cell Membrane
|
| Specificity |
The antibody MEM-233 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD80
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for B7-1/CD80 Antibody (MEM-233)
- Activation B7-1 antigen
- B7
- B71
- B7-1
- BB1
- CD28LG1
- CD28LGB7-1 antigen)
- CD80 antigen
- CD80 molecule
- CD80
- costimulatory factor CD80
- costimulatory molecule variant IgV-CD80
- CTLA-4 counter-receptor B7.1
- T-lymphocyte activation antigen CD80
Background
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.