Product: Benzenepentacarboxylic Acid
Autoimmune Regulator/AIRE Antibody Summary
| Immunogen |
Peptide with sequence C-KAKPPKKPESSAEQ corresponding to internal region according to NP_000374.1, NP_000649.1.
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| Epitope |
KAKPPKKPESSAEQ
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
AIRE
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 55 kDa band observed in human spleen lysates (calculated MW of 57.7 kDa band according to NP_000374.1).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Rat, Porcine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Autoimmune Regulator/AIRE Antibody
- AIRE
- APECED protein
- APECED
- APECEDAPSI
- APS1
- APSI
- Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
- autoimmune regulator (APECED protein)10APS1AIRE1
- autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermaldystrophy)
- Autoimmune Regulator
- PGA1
Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).