Angiopoietin-like Protein 4/ANGPTL4 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to residues C(80) Q G P K G K D A P F K D S E(94) of mouse FIAF.
|
| Localization |
Secreted, extracellular space, extracellular matrix (By similarity). Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of FIAF.
|
| Isotype |
IgG
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| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ANGPTL4
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS, 1 mg/ml BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Angiopoietin-like Protein 4/ANGPTL4 Antibody
- Angiopoietin like Protein 4
- angiopoietin-like 4
- Angiopoietin-like Protein 4
- ANGPTL4
- ARP4fasting-induced adipose factor
- FIAF
- FIAFhepatic angiopoietin-related protein
- Hepatic fibrinogen/angiopoietin-related protein
- HFARP
- HFARPANGPTL2
- NL2
- peroxisome proliferator-activated receptor (PPAR) gamma inducedangiopoietin-related protein
- PGAR
- PGARangiopoietin-related protein 4
- pp1158
- PPARG angiopoietin related protein
Background
Adipose tissue is an energy reserve in animals, and in nondomestic species it is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and Acrp30. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor alpha (PPAR alpha). PPAR alpha has recently been reported to target a novel gene encoding the secreted protein FIAF (fasting-induced adipose factor). FIAF is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that FIAF represents a novel endocrine signal helping to regulate metabolism, especially under fasting conditions.