Alkaline Phosphatase, Tissue Non-Specific Antibody (4H1) Summary
| Immunogen |
ALPL (AAH21289, 91 a.a. – 200 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. WRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSR
|
| Specificity |
ALPL – alkaline phosphatase, liver/bone/kidney
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ALPL
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has been used for RNAi Validation and ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Alkaline Phosphatase, Tissue Non-Specific Antibody (4H1)
- Alkaline phosphatase liver/bone/kidney isozyme
- alkaline phosphatase, liver/bone/kidney
- alkaline phosphatase, tissue-nonspecific isozyme
- alkaline phosphomonoesterase
- APTNAP
- AP-TNAP
- EC 3.1.3.1
- FLJ40094
- FLJ93059
- glycerophosphatase
- HOPS
- liver/bone/kidney-type alkaline phosphatase
- MGC161443
- tissue-nonspecific ALP
- TNAP
- TNSALPMGC167935
Background
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.