Aggrecan Antibody (661725) – (ADAMTS5-cleaved) Summary
| Immunogen |
KLHG-conjugated peptide from human Aggrecan, Leu384-Glu392
Accession # P16112 |
| Specificity |
Detects human Aggrecan in direct ELISAs. It specifically recognizes the N-terminal fragment of recombinant human Aggrecan released following cleavage by ADAMTS5.
|
| Source |
N/A
|
| Isotype |
IgG3
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ACAN
|
| Purity |
Protein A or G purified from hybridoma culture supernatant
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
|
| Preservative |
No Preservative
|
| Concentration |
LYOPH
|
| Purity |
Protein A or G purified from hybridoma culture supernatant
|
| Reconstitution Instructions |
Sterile PBS to a final concentration of 0.5 mg/mL.
|
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Aggrecan Antibody (661725) – (ADAMTS5-cleaved)
- ACAN
- AGC1
- AGC1SEDK
- aggrecan core protein
- Aggrecan
- Cartilage-specific proteoglycan core protein
- Chondroitin sulfate proteoglycan 1
- Chondroitin sulfate proteoglycan core protein 1
- CSPCP
- CSPG1
- CSPG1aggrecan 1
- CSPGCP
- large aggregating proteoglycan
- MSK16
- MSK16AGCAN
- SEDK
Background
Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20‑675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD). The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.