Product: Olcegepant (hydrochloride)
ASC/TMS1 Antibody Summary
| Immunogen |
PYCARD (1 a.a. ~ 150 a.a) full-length human protein.MDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFNFTPAWNWTCKDLLLQALRESQSYLVEDLERS
|
| Specificity |
PYCARD – PYD and CARD domain containing,
|
| Clonality |
Polyclonal
|
| Host |
Mouse
|
| Gene |
PYCARD
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
Protein A purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for ASC/TMS1 Antibody
- ASC
- ASCMGC10332
- CARD5
- CARD5TMS
- caspase recruitment domain protein 5
- Caspase recruitment domain-containing protein 5
- hASC
- PYCARD
- PYD and CARD domain containing
- PYD and CARD domain-containing protein
- Target of methylation-induced silencing 1
- TMS1
- TMS-1
- TMS1apoptosis-associated speck-like protein containing a CARD
Background
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]