APPL Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human APPL1. The exact sequence is proprietary.
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| Predicted Species |
Porcine (98%), Bovine (99%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
APPL1
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| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (89%), Zebrafish (86%),.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for APPL Antibody
- Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
- adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zippercontaining 1
- AKT2 interactor
- APPL
- APPL1
- APPLdip13-alpha
- DCC-interacting protein 13-alpha
- DIP 13 alpha
- DIP13A
- DIP13alpha
- Dip13-alpha
- KIAA1428
- signaling adaptor protein DIP13alpha
Background
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq]