ANP32A Antibody Summary
| Immunogen |
Antibody was raised with a synthetic peptide corresponding to amino acids close to carboxy terminus of human PHAP I. The sequence is identical between human and rat PHAP I. The immunogen is located within the last 50 amino acids of PHAP I.
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| Specificity |
This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ANP32A
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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| Theoretical MW |
32 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
This sequence is identical between human and rat PHAP I.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for ANP32A Antibody
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
- acidic leucine-rich nuclear phosphoprotein 32 family member A
- Acidic nuclear phosphoprotein pp32
- cerebellar leucine rich acidic nuclear protein
- I1PP2A
- inhibitor-1 of protein phosphatase-2A
- LANPPutative HLA-DR-associated protein I
- Leucine-rich acidic nuclear protein
- MAPMC15orf1
- mapmodulin
- PHAP1MGC150373
- PHAPIMGC119787
- Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
- PP32
- putative human HLA class II associated protein I
Background
PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.