AMPD3 Antibody (AMPD3/901) [DyLight 350] Summary
| Immunogen |
Recombinant full-length human AMDP3 protein
|
| Localization |
Cell Surface
|
| Marker |
Erythroid Marker
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| Specificity |
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
AMPD3
|
| Purity |
Protein A or G purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for AMPD3 Antibody (AMPD3/901) [DyLight 350]
- adenosine monophosphate deaminase (isoform E)
- adenosine monophosphate deaminase 3
- AMP aminohydrolase
- AMP deaminase 3
- AMP deaminase isoform E
- EC 3.5.4.6
- Erythrocyte AMP deaminase
- erythrocyte type AMP deaminase
- erythrocyte-specific AMP deaminase
- myoadenylate deaminase