Product: o-Dianisidine (dihydrochloride)
AMBRA1 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 1200 and 1250 of human AMBRA1 [BAG64009.1] (GeneID 55626).
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| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
AMBRA1
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| Purity |
Immunogen affinity purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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| Theoretical MW |
143 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla and Chimpanzee.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
TBS and 0.1% BSA
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for AMBRA1 Antibody
- activating molecule in BECN1-regulated autophagy protein 1
- autophagy/beclin-1 regulator 1
- DCAF3
- DDB1 and CUL4 associated factor 3
- FLJ20294
- KIAA1736activating molecule in beclin-1-regulated autophagy
- MGC33725
- WD repeat domain 94
- WDR94
Background
AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.