ALK/CD246 Antibody (SP8) Summary
| Immunogen |
Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
|
| Localization |
Cell Membrane
|
| Specificity |
This antibody recognises a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This rabbit monoclonal antibody can be used to detect p80 in these lymphomas and may also be used to detect a recently described subtype of large B cell lymphoma, which expresses the full-length ALK protein.
|
| Isotype |
IgG
|
| Clonality |
Monoclonal
|
| Host |
Rabbit
|
| Gene |
ALK
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tissue culture supernatant
|
| Preservative |
15mM Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for ALK/CD246 Antibody (SP8)
- ALK tyrosine kinase receptor
- ALK
- anaplastic lymphoma kinase (Ki-1)
- Anaplastic lymphoma kinase
- anaplastic lymphoma receptor tyrosine kinase
- CD246 antigen
- CD246
- EC 2.7.10.1
- Ki-1
- NBLST3
- Tcrz
Background
Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte tyrosine kinase) are receptor tyrosine kinases similar to the insulin receptor subfamily of kinases. LTK is found in murine B Lymphocyte precursors and in forebrain neurons. ALK is usually found in the nervous system. A truncated form of ALK occurs in many non Hodgkins lymphomas. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 [t(2;5}], the ALK gene fuses with the NPM gene. NPM, also known as B23, is an ubiquitous nucleolar phosphoprotein involved in the transport of pre ribosomal components between the nucleolus and the cytoplasm. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. Karpas 299 and SUDHL1 lymphoid cell lines strongly express NPM ALK.