ALDH2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human ALDH2. The exact sequence is proprietary.
|
| Localization |
Mitochondrion matrix
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| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ALDH2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (83%) and Xenopus tropicalis (84%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ALDH2 Antibody
- acetaldehyde dehydrogenase 2
- aldehyde dehydrogenase 2 family (mitochondrial)
- aldehyde dehydrogenase, mitochondrial
- ALDH class 2
- ALDH-E2
- ALDHI
- ALDM
- EC 1.2.1
- EC 1.2.1.3
- liver mitochondrial ALDH
- MGC1806
- nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Background
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.