ACK1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human ACK1. The exact sequence is proprietary.
|
| Localization |
Cell membrane
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TNK2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ACK1 Antibody
- ACK-1
- ACK1ACKp21cdc42Hs
- activated CDC42 kinase 1
- activated Cdc42-associated kinase 1
- activated p21cdc42Hs kinase
- EC 2.7.10
- EC 2.7.10.2
- FLJ44758
- FLJ45547
- Tyrosine kinase non-receptor protein 2
- tyrosine kinase, non-receptor, 2
Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.