5-HT4 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT4 Receptor.
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| Specificity |
Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Mouse (94%), Rat (94%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
HTR4
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (88%), Hamster 988%), Elephant (88%), Panda (88%), Canine (88%), Equine (88%), Guiena Pig (88%), Bat (81%), Rabbit (81%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for 5-HT4 Antibody
- 5HT4
- 5-HT4
- 5-HT-4
- 5-HT4R
- 5-hydroxytryptamine (serotonin) receptor 4,5-hydroxytryptamine receptor 4,5-HT45-hydroxytryptamine4 receptor
- cardiac 5-HT4 receptor
- HTR4
- Serotonin receptor 4
Background
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.