14-3-3 zeta/beta [p Ser185] Antibody Summary
| Immunogen |
Synthetic peptide corresponding to 14-3-3 beta and zeta phosphorylated at serine 185.
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| Modification |
p Ser185
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| Specificity |
NB100-62101 recognizes the 14-3-3 isoforms beta and zeta which are phosphorylated at serine 185. The members of the 14-3-3 family of proteins are highly conserved and are involved in multiple signalling pathways. The phosphorylated forms of beta and zeta 14-3-3 are found endogenously in brain tissue.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Sheep
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| Gene |
YWHAZ
|
| Purity |
IgG purified
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
No buffer
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| Preservative |
0.09% Sodium Azide
|
| Purity |
IgG purified
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Alternate Names for 14-3-3 zeta/beta [p Ser185] Antibody
- KCIP-1MGC126532,14-3-3-zeta
- MGC111427
- MGC138156
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, deltapolypeptide
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zetapolypeptide
- zeta polypeptide
Background
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.