Colorectal cancer is one of the most common diagnosed malignancies in the world

As the optimization presented here is directed at restoring normal homeostasis instead of transitory response it may not be unexpected to find a focus on remediation of Th1 activity as a key component of the prescribed treatment course. PLOS ONE | DOI:10.1371/journal.pone.0132774 July 20, 2015 12 / 16 Achieving Remission in Gulf War Illness While it appears that a Th1 imbalance is a component in GWI, to our knowledge there have been no studies examining Th1 inhibition in GWI. Certain autoimmune conditions, specifically multiple sclerosis and uveitis that involve inflammation of neurological tissue, have shown responsiveness to anti-IL2R antibodies [30�34]. Two anti-IL2R antibodies commonly used in transplant rejection therapy, daclizumab and basiliximab, have undergone phase II trials for MS and uveitis, however neither of them are currently on the market [30]. Anti-IFN-g treatment also appears to improve Th1 autoimmune diseases, including MS and RA [35]. Specifically, randomized studies of antibodies to IFN-g showed statistically significant improvement in disability progression in secondary progressive MS [36], and improved symptoms in RA [37]. To our knowledge, no trials of anti-IL-2 or anti-IFNg in the treatment of GWI are currently under investigation. Hypercortisolism, excess levels of the stress hormone cortisol, has been IMR 1 site pubmed ID:http://www.ncbi.nlm.nih.gov/pubmed/19667063 observed in patients suffering from a number of conditions PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19666218 including the muscle wasting condition Cushing’s syndrome [38,39], the memory deteriorating Alzheimer’s disease [40,41], and chronic pain [42,43]. Experimental data reported previously by this group [25] indicate that GWI subjects tend to present with chronically elevated levels of CORT. Glucocorticoid receptor antagonists, which block t