HDAC3 enzymatic activity can be regulated by phosphorylation/dephosphorylation [17,18] as well as indirectly regulated through phosphorylation of its associated proteins.
For example, HDAC3 can deacetylate non-histone proteins, this kind of as MEF2 [14], NF-kB [fifteen], and retinoblastoma protein (pRB) [sixteen].…