We suggest that AL1ICD does not have a immediate physiological part in transcriptional regulation, but by way of sequestration of Fe65 by APLP1 this household member might act as a repressor of AICD-mediated nuclear signaling
Schematic presentation of App family ICD sequences and Application/APLP1 mutations. c.s.: cleavage web site b.s.: binding internet site. doi:ten.1371/journal.pone.0069363.g005 Figure…