Give our existing obtaining that DKK1 inhibits autocrine canonical Wnt signaling in MM cells, inhibition of DKK1 could hyperactivate the Wnt pathway and thus advertise tumor expansion, especially at extramedullary web sites
In addition, in LME-one, a cell line with a hypermethylated DKK1 promoter and reduced DKK1 expression, DKK1 expression 79831-76-8was enhanced…