As mono-ubiquitination does not guide to protein degradation and can be reverted by deubiquitinating enzymes (DUBs), we screened a overall of 70 DUBs for their capacity to inhibit Ub-PDK1 on overexpression (Determine 4A)
PDK1 shuttles among the nucleus and the cytoplasm in a CRM1-dependent and expansion component controlled way but the practical significance…