Multiple unbiased oligonucleotides (four oligos/transcript) ended up created to target the Jumonji C (JmjC)-area-containing proteins, the lysine specific demethylase 1 (LSD1)-like family customers, methyl CpG binding proteins and DNA methylases (see Supplemental table S1 for sequences)
Chromatin is thoroughly modified throughout senescence to permit selective repression of E2F-target genes that manage cellular proliferation. E2F-target gene promoters…